Sarcoglycans and integrins in human thyrocytes: an immunofluorescence study

The sarcoglycan sub-complex is a protein system which plays key role in sarcolemma stabilization during muscle activity consisting of six glycosylated transmembrane proteins. Integrins play the process cell adhesion, linking extracellular matrix to actin cytoskeleton. Here we have analysed receptor for thyroid hormone, identified on αvβ3-integrin that has an important activation non-genomic actions hormone. Many hormone appear contribute basal levels variety proteins, including ion pumps, intracellular trafficking and turnover. purpose our research was study presence behaviour sarcoglycans integrins gland, both normal pathological conditions, first time. Our results show fluorescence pattern patients without pathology, reduced with disease. Moreover, colocalization healthy found double localization reactions, whereas Hashimoto’s thyroiditis did not colocalize tested integrin. These data could confirm hypothesis close association between integrins, which, condition, are contemporarily hypothesizing each single maintaining vitality.